Frontline Combo, though similar to Frontline Spot On requires a prescription as it contains a second active ingredient, (S)-methoprene, to prevent the development of flea eggs, larvae and pupae around your home. The development of Frontline Combo reflects the advice of flea control experts who recommend a multiple approach to the flea problem, with the use of more than one active compound (one to control adult fleas and one to control the immature forms which live around the pet‘s environment and not on the pet itself) plus mechanical control methods such as regular vacuuming and washing of your pet’s bedding.
Simply applied as a low volume liquid ‘spot-on’ on the back of your pet’s neck Frontline Combo far exceeds shampoos and other treatments in terms of convenience, efficacy and pet-acceptance. Once applied, Frontline Combo spreads over the entire surface of your pet's body, collecting in the 'oil glands' of the skin to achieve a reservoir effect. This keeps the level of the active ingredients on the body surface sufficient to provide flea control for the whole dosage interval. Frontline Combo has many benefits to offer:
Breaks the flea life-cycle
Eliminates adult fleas on your pet within 24 hours
Prevents multiplication of fleas in your home
Eliminates ticks and lice within 48 hours
Applied and distributed externally
Acts by direct contact and not via your pet's bloodstream
Can be used during pregnancy and lactation
Need only be applied every 6 weeks in dogs that are being shampooed weekly.

Prescription Required